A comparative analysis of business process modelling techniques

Business process modelling is an increasingly popular research area for both organisations and academia due to its usefulness in facilitating human understanding and communication. Several modelling techniques have been proposed and used to capture the characteristics of business processes. However, available techniques view business processes from different perspectives and have different features and capabilities. Furthermore, to date limited guidelines exist for selecting appropriate modelling techniques based on the characteristics of the problem and its requirements. This paper presents a comparative analysis of some popular business process modelling techniques. The comparative framework is based on five criteria: flexibility, ease of use, understandability, simulation support and scope. The study highlights some of the major paradigmatic differences between the techniques. The proposed framework can serve as the basis for evaluating further modelling techniques and generating selection procedures

Semantic discovery and reuse of business process patterns

Patterns currently play an important role in modern information systems (IS) development and their use has mainly been restricted to the design and implementation phases of the development lifecycle. Given the increasing significance of business modelling in IS development, patterns have the potential of providing a viable solution for promoting reusability of recurrent generalized models in the very early stages of development. As a statement of research-in-progress this paper focuses on business process patterns and proposes an initial methodological framework for the discovery and reuse of business process patterns within the IS development lifecycle. The framework borrows ideas from the domain engineering literature and proposes the use of semantics to drive both the discovery of patterns as well as their reuse

A Semantic-based framework for discovering business process patterns

Patterns currently play an important role in modern information systems (IS) development and their use has mainly been restricted to the design and implementation phases of the development lifecycle. Given the increasing significance of business modeling in IS development, patterns have the potential of providing a viable solution for promoting reusability of recurrent generalized models in the very early stages of development. This paper focuses on business process patterns and proposes an initial framework for the discovery and reuse of business process patterns within the IS development lifecycle. The framework synthesizes the idea from the domain engineering literature and proposes the use of semantics to drive both the discovery of patterns as well as their reuse

Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients

The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. In this study we report the frequencies of BCR-ABL1 fusion transcript variants studied in 43 CML patients from Sudan. The study includes 46 Sudanese patients, three of which negative for the BCR-ABL1 fusion transcript. More than half of 43 positive patients showed b2a2 fusion transcript (53.5%), while (41.9%) showed b3a2 transcript and the remaining (4.6%) coexpression of b3a2/ b2a2 and b3a2/b2a2/e19a2. We detected neither coexpression of p210/p190 nor e1a2 alone. Male patients showed a tendency to express b2a2, while female tende to express b3a2 (p = 0.017). Moreover, a single nucleotide polymorphism was detected in BCR exon 13 in one out of four patients and this patient showed only b2a2 expression. In conclusion, we observed a significant correlation between sex and type of BCR-ABL1 transcript, an observation that deserves further investigation

Slaughterhouse Wastewater Treatment by Combined Chemical Coagulation and Electrocoagulation Process

Slaughterhouse wastewater contains various and high amounts of organic matter (e.g., proteins, blood, fat and lard). In order to produce an effluent suitable for stream discharge, chemical coagulation and electrocoagulation techniques have been particularly explored at the laboratory pilot scale for organic compounds removal from slaughterhouse effluent. The purpose of this work was to investigate the feasibility of treating cattle-slaughterhouse wastewater by combined chemical coagulation and electrocoagulation process to achieve the required standards. The influence of the operating variables such as coagulant dose, electrical potential and reaction time on the removal efficiencies of major pollutants was determined. The rate of removal of pollutants linearly increased with increasing doses of PACl and applied voltage. COD and BOD5 removal of more than 99% was obtained by adding 100 mg/L PACl and applied voltage 40 V. The experiments demonstrated the effectiveness of chemical and electrochemical techniques for the treatment of slaughterhouse wastewaters. Consequently, combined processes are inferred to be superior to electrocoagulation alone for the removal of both organic and inorganic compounds from cattle-slaughterhouse wastewater

Automatsko brojanje putnika u javnom željezničkom prijevozu uporabom waveleta

Previously, we introduced a passengers’ counting algorithm in public rail transport. The main disadvantage of that algorithm is it lacks automatic event detection. In this article, we implement two automatic wavelet-based passengers counting algorithms. The new algorithms employ the spatial-domain Laplacian-of-Gaussian-based wavelet, and the frequency-domain applied Non-Linear Difference of Gaussians-based wavelet bandpass video scene filters to extract illumination invariant scene features and to combine them efficiently into the background reference frame. Manual segmentation of the scene into rectangles and tiles for detecting an object as seated is no longer needed as we now apply a boundary box tracker on the segmented moving objects’ blobs. A scene map is combined with the wavelet-based methods and the boundary box for multi-camera object registration. We have developed a novel holistic geometrical approach for exploiting the scene map and the recorded video sequences from both cameras installed in each train coach to separate the detected objects and locate their positions on the scene map. We test all the algorithms with several video sequences recorded from the both cameras installed in each train coach. We compare the previously developed non-automatic passengers’ counting algorithm with the two new automatic wavelet-based passengers’ counting algorithms, and an additional spatial-domain automatic non-wavelet based Simple Mixture of Gaussian Models algorithm.U prethodnim radovima uveli smo algoritam za brojanje putnika u javnom željezničkom prijevozu. Glavna manjkavost dosadašnjeg algoritma odsustvo je sustava za automatsko otkrivanje događaja. U ovom radu implementirali smo dva algoritma za automatsko brojanje putnika temeljena na waveletima. Novi algoritmi koriste LoG (Laplacian-of-Gaussian-based) wavelete u prostornoj domeni i pojasne filtre temeljene na waveletima nastalim na nelinearnim razlikama Gaussovih funkcija u frekvencijskoj domeni, pomoću kojih se izdvajaju značajke neosjetljive na razlike u osvjetljenju iz pojedine scene. Te značajke kombiniraju se u referentnu sliku koja prikazuje pozadinu scene. Ručna segmentacija scene u pravokutnike korištena u prethodnom algoritmu više nije potrebna jer se sada koristi automatsko praćenje rubova na segmentiranim objektima. Mapa scene kombinirana je s wavelet metodama i okvirom granica slike u svrhu registracije objekata pomoću više kamera. Razvili smo i novi cjeloviti geometrijski pristup koji koristi mapu scene i snimljeni videozapis iz dvije kamere postavljene u svakom vagonu vlaka pomoću kojeg možemo odvojiti detektirane objekte i locirati njihove položaje na mapi scene. Algoritmi su ispitani na nekoliko videosekvenci snimljenih s dvije kamere u vagonima. Usporedili smo ranije razvijene neautomatske algoritme za brojanje putnika s dva nova algoritma i s jednostavnim MoG algoritmom u prostornoj domeni

Interim PET-results for prognosis in adults with Hodgkin lymphoma: a systematic review and meta-analysis of prognostic factor studies

Background Hodgkin lymphoma (HL) is one of the most common haematological malignancies in young adults and, with cure rates of 90%, has become curable for the majority of individuals. Positron emission tomography (PET) is an imaging tool used to monitor a tumour’s metabolic activity, stage and progression. Interim PET during chemotherapy has been posited as a prognostic factor in individuals with HL to distinguish between those with a poor prognosis and those with a better prognosis. This distinction is important to inform decision‐making on the clinical pathway of individuals with HL. Objectives To determine whether in previously untreated adults with HL receiving first‐line therapy, interim PET scan results can distinguish between those with a poor prognosis and those with a better prognosis, and thereby predict survival outcomes in each group. Search methods We searched MEDLINE, Embase, CENTRAL and conference proceedings up until April 2019. We also searched one trial registry (ClinicalTrials.gov). Selection criteria We included retrospective and prospective studies evaluating interim PET scans in a minimum of 10 individuals with HL (all stages) undergoing first‐line therapy. Interim PET was defined as conducted during therapy (after one, two, three or four treatment cycles). The minimum follow‐up period was at least 12 months. We excluded studies if the trial design allowed treatment modification based on the interim PET scan results. Data collection and analysis We developed a data extraction form according to the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (CHARMS). Two teams of two review authors independently screened the studies, extracted data on overall survival (OS), progression‐free survival (PFS) and PET‐associated adverse events (AEs), assessed risk of bias (per outcome) according to the Quality in Prognosis Studies (QUIPS) tool, and assessed the certainty of the evidence (GRADE). We contacted investigators to obtain missing information and data. Main results Our literature search yielded 11,277 results. In total, we included 23 studies (99 references) with 7335 newly‐diagnosed individuals with classic HL (all stages). Participants in 16 studies underwent (interim) PET combined with computed tomography (PET‐CT), compared to PET only in the remaining seven studies. The standard chemotherapy regimen included ABVD (16) studies, compared to BEACOPP or other regimens (seven studies). Most studies (N = 21) conducted interim PET scans after two cycles (PET2) of chemotherapy, although PET1, PET3 and PET4 were also reported in some studies. In the meta‐analyses, we used PET2 data if available as we wanted to ensure homogeneity between studies. In most studies interim PET scan results were evaluated according to the Deauville 5‐point scale (N = 12). Eight studies were not included in meta‐analyses due to missing information and/or data; results were reported narratively. For the remaining studies, we pooled the unadjusted hazard ratio (HR). The timing of the outcome measurement was after two or three years (the median follow‐up time ranged from 22 to 65 months) in the pooled studies. Eight studies explored the independent prognostic ability of interim PET by adjusting for other established prognostic factors (e.g. disease stage, B symptoms). We did not pool the results because the multivariable analyses adjusted for a different set of factors in each study. Overall survival Twelve (out of 23) studies reported OS. Six of these were assessed as low risk of bias in all of the first four domains of QUIPS (study participation, study attrition, prognostic factor measurement and outcome measurement). The other six studies were assessed as unclear, moderate or high risk of bias in at least one of these four domains. Nine studies were assessed as high risk, and three studies as moderate risk of bias for the domain study confounding. Eight studies were assessed as low risk, and four studies as high risk of bias for the domain statistical analysis and reporting. We pooled nine studies with 1802 participants. Participants with HL who have a negative interim PET scan result probably have a large advantage in OS compared to those with a positive interim PET scan result (unadjusted HR 5.09, 95% confidence interval (CI) 2.64 to 9.81, I² = 44%, moderate‐certainty evidence). In absolute values, this means that 900 out of 1000 participants with a negative interim PET scan result will probably survive longer than three years compared to 585 (95% CI 356 to 757) out of 1000 participants with a positive result. Adjusted results from two studies also indicate an independent prognostic value of interim PET scan results (moderate‐certainty evidence). Progression‐free survival Twenty‐one studies reported PFS. Eleven out of 21 were assessed as low risk of bias in the first four domains. The remaining were assessed as unclear, moderate or high risk of bias in at least one of the four domains. Eleven studies were assessed as high risk, nine studies as moderate risk and one study as low risk of bias for study confounding. Eight studies were assessed as high risk, three as moderate risk and nine as low risk of bias for statistical analysis and reporting. We pooled 14 studies with 2079 participants. Participants who have a negative interim PET scan result may have an advantage in PFS compared to those with a positive interim PET scan result, but the evidence is very uncertain (unadjusted HR 4.90, 95% CI 3.47 to 6.90, I² = 45%, very low‐certainty evidence). This means that 850 out of 1000 participants with a negative interim PET scan result may be progression‐free longer than three years compared to 451 (95% CI 326 to 569) out of 1000 participants with a positive result. Adjusted results (not pooled) from eight studies also indicate that there may be an independent prognostic value of interim PET scan results (low‐certainty evidence). PET‐associated adverse events No study measured PET‐associated AEs. Authors' conclusions This review provides moderate‐certainty evidence that interim PET scan results predict OS, and very low‐certainty evidence that interim PET scan results predict progression‐free survival in treated individuals with HL. This evidence is primarily based on unadjusted data. More studies are needed to test the adjusted prognostic ability of interim PET against established prognostic factors.</p